Klotho is a transmembrane protein which has control over the insulin sensitivity, regeneration and aging. Transgenic mice overexpressing Klotho protein live longer than wild-type mice. The, variations in the Klotho gene (SNP Rs9536314) are associated with both life extension and increased cognition in human populations. It is possible to induce Klotho levels in human by several means, like exercises or stress reduction measures.