Aging is one of the central risk factors for cancer development. Consequently, the fight against aging and the prevention / treatment of cancer are closely related to each other. In this group the latest achievements in the field of oncology are collected: advanced diagnostics, effective prevention, cure and targeting.

Longevity is determined by complex interactions between external and internal factors. Genetic factor is a basic component that conditions the potential features of an organism including life expectancy. The numerous of studies identified the wide range of genes determined life span of different organisms as well as genetic loci associated with exceptional longevity and wellness. This group illustrates key researches that are making the progress in the study of such genes and their loci.

Klotho is a transmembrane protein which has control over the insulin sensitivity, regeneration and aging. Transgenic mice overexpressing Klotho protein live longer than wild-type mice. The, variations in the Klotho gene (SNP Rs9536314) are associated with both life extension and increased cognition in human populations. It is possible to induce Klotho levels in human by several means, like exercises or stress reduction measures.

Aging can be slowed by many potential interventions; dietary, nutraceutical, and pharmacologic interventions are the most promising candidates to slow aging. Do we have anything effective available or the evidence is not yet there?

Metformin is the first-line medication for the treatment of type 2
diabetes. Interestingly, it may prevent the cardiovascular disease and cancer. A 2014 research study has provided data, that patients treated with metformin had longer lifespans. This group informs the community about the latest advancement on this front.