Publications

What determines an exceptional life expectancy - the genetic characteristics of an individual or his lifestyle and environmental conditions? The insightful review about the contribution of genetic, epigenetic and environmental factors in the formation of human lifespan.Authors: Diddahally Govindarajua, Gil Atzmonb, and N...

​A new artcle about the basis of aging and its relationship to the process known as mitophagy.​Author: Michael SternSummaryThe antagonistic pleiotropy (AP) theory posits that aging occurs because alleles that are detrimental in older organisms are beneficial to growth early in life and thus are maintained in populations. Although gen...

Recently, an interesting study to metformin was carried out. It turned out that this medication with the known antidiabetic and geroprotective activity has also potential anticancer effect. Authors: Yong Lei, Yanhua Yi, Yang Liu, Xia Liu, Evan T. Keller, Chao-Nan Qian, Jian Zhang, and Yi Lu...

Interesting review in Trends in Molecular Medicine journal about senescent cells and their interaction with environment. Different approaches for elimination are discussed with focus on cell-penetrating peptides, which may prove themselves as promising therapeutic candidates. Involvement of individual FOXO signaling pathways are transiently touc...

The article summarizes the mechanisms by which cellular senescence can promote aging and possible therapeutic interventions specifically targeting senescent cells. pdf File Name: Therapeutic-interventions-for-aging-the-case-of-cellular-senescence-2016.pdf ...