Aging of the cardiovascular system is a prerequisite for the human senescence. Interestingly, this process is closely related to the activity of micro RNAs.
Authors: Seahyoung Lee, Eunhyun Choi, Min-Ji Cha, Ae-Jun Park, Cheesoon Yoon, and Ki-Chul Hwang
Abstract
Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs (miRNAs) have been shown to regulate gene expression, which contributes to many physiological and pathophysiological processes in humans. Increasing evidence suggests that changes in miRNA expression profiles contribute to cellular senescence, aging and aging-related diseases. However, only a few miRNAs whose functions have been elucidated have been associated with aging and/or aging-related diseases. This article reviews the currently available findings regarding the roles of aging-related miRNAs, with a focus on cardiac and cardiovascular aging.
