Publications

​Death rates in later life flatten out and suggest there may be no fixed limit on human longevity, countering some previous work.Author: Elie DolginThere might be no natural limit to how long humans can live — at least not one yet in sight — contrary to the claims of some demographers and biologists.That's according to a statistical analysis publis...

Author: Richard FaragherMaking a drug is like trying to pick a lock at the molecular level. There are two ways in which you can proceed. You can try thousands of different keys at random, hopefully finding one that fits. The pharmaceutical industry does this all the time – sometimes screening hundreds of thousands of compounds to ...

Scientists from Yale University conducted a new study of the functions of the fibroblast growth factor FGF21 that binds and is mediated by the longevity protein beta-Klotho.​​Author: Ziba KashefNamed after the Greek goddess who spun the thread of life, Klotho proteins play an important role in the regulation of longevity and metaboli...

The evolutionarily conserved enzyme RNA polymerase III is a driver of protein synthesis and cell growth. It emerges that partial suppression of this essential enzyme extends lifespan in yeast, roundworms and flies.Authors: Bruce A. Edgar & Savraj S. Grewal​Gene transcription in animal and fungal cells is accomplished by three RNA polymeras...

A recent detailed review of cellular and molecular mechanism of cellular senescence and aging, as well as their therapevtic application.​Authors: Domhnall McHugh and Jesús GilAbstractAging is the major risk factor for cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. Although we are far from understanding the biologica...

A detailed review about the role of epigenetic mechanisms in genomic stability changes and the aging process.Authors: Sangita Pal and Jessica K. TylerAbstractOver the past decade, a growing number of studies have revealed that progressive changes to epigenetic information accompany aging in both dividing and nondividing cells. Functional ...

​A latest review about molecular and cellular mechanisms of aging.​Authors: João Pedro de Magalhães, João F.PassosHighlights• Cellular senescence is the irreversible arrest of normally dividing cells.• Telomere shortening is the mechanism driving senescence in human fibroblasts.• Olivier Toussaint and others have shown that stress plays a majo...

​​Author: Andrew JosephBeing smarter as a child means you are more likely to live longer than people of lower intelligence, according to the most comprehensive study yet to look at the connection between IQ and longevity and that analyzed a sweeping range of causes of death, from injuries to dementia to heart disease.Among the thousands of peo...

Surprisingly, the elasticity of blood vessels in the elderly, not suffering from diabetes and obesity, can be at the level of a healthy middle-age man.​Authors: Teemu J. Niiranen, Asya Lyass, Martin G. Larson, Naomi M. Hamburg, Emelia J. Benjamin, Gary F. Mitchell, and Ramachandran S. VasanAbstractHypertension and increased vascul...

An exellent review of methods for assessing the biological age from Dr. S. Michal Jazwinski.​Authors: S. Michal Jazwinski and Sangkyu KimAbstractBiological age is a concept that takes into account the heterogeneity of the aging process in different individuals that results in differences in survival and variations in relative health. Any ...

Professor Mikhail V. Blagosklonny presented an interesting review about the efficiency of a combination of various geroprotectors and life extension methods.​Author: Mikhail V. BlagosklonnyAbstractInhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which s...

Immunosenescence is the age-dependent deficiency in the immune system functioning. This is one of the most important components of the aging of the whole organism, and it is based on the deregulation of a complicated protein system. One of the key proteins is interleukin 7 (IL-7), which is the subject of this review.  Authors: ...

Heart health radically affects the human wellness. In addition, diseases of this organ are one of the main causes of martality and deterioration of the common health of elderlies. Recently, a review devoted to aging and cardiac pathophysiology has been published.​Authors: Marja Steenman and Gilles LandeAbstractThe world population co...

An informative article about a new approach in assessing the rate of aging, probable life expectancy and health status of patients.Authors: Luke Oakden-Rayner, Gustavo Carneiro, Taryn Bessen, Jacinto C. Nascimento, Andrew P. Bradley & Lyle J. Palmer​AbstractPrecision medicine approaches rely on obtaining precise knowledge of t...

A study of the new SIRT6 polimorphism rs117385980 that determine aging rate and long life.Authors: Katariina Hirvonen, Hannele Laivuori, Jari Lahti, Timo Strandberg, Johan G. Eriksson, and Peter HackmanAbstractBackgroundSirtuin-6 (SIRT6) is involved in various crucial cellular pathways, being a key regulator of telomere structure,...

A new bioinformatics study about the determinants of aging and the contribution of the genetic component to this process.​Authors: Robert Häsler, Geetha Venkatesh, Qihua Tan, Friederike Flachsbart, Anupam Sinha, Philip Rosenstiel, Wolfgang Lieb, Stefan Schreiber, Kaare Christensen, Lene Christiansen, Almut NebelAbstractHuman longevity is a com...

Telomere theory is one of the popular theories of aging. Recently, a new study was conducted on the relationship between the telomere length and the maximum lifespan of humans.​Authors: Troels Steenstrup, Jeremy D. Kark, Simon Verhulst, Mikael Thinggaard, Jacob V. B. Hjelmborg, Christine Dalgård, Kirsten Ohm Kyvik, Lene Chris...

The latest study of molecular mechanisms of longevity and their correction by nutritional programming.​Authors: Adam J. Dobson, Marina Ezcurra, Charlotte E. Flanagan, Adam C. Summerfield, Matthew D.W. Piper, David Gems, Nazif AlicAbstractConsumption of unhealthy diets is exacerbating the burden of age-related ill health in ag...

Circadian clock is one of key regulators of organism functions and longevity. In the latest article, the possibility of regulating circadian rhythms of mammals by using specific small molecules is considered. Perhaps, this discovery will reveal a new treatment against aging.​Authors: Gabrielle F. Gloston, ...

While the search for elixir of life has captivated human imagination for millennia, researchers around the world have put in efforts to extend healthy lifespan and reduce the burden of morbid diseases in an increasingly aging population. Research over the past two decades has demonstrated how Sirtuin 1 (SIRT1) (popularly known as longevity gene) de...